BERNARD, Claude (1813-78). Introduction à l' Étude de la Médecine Expérimentale, Paris, 1856, 8vo, original grey printed wrappers. FIRST EDITION, second issue.

BERNARD, Claude (1813-78).  Introduction  l' Étude de la Médecine Expérimentale. Paris, London & Madrid: J. B. Baillière et Fils [on verso of half title and verso of p.400:] Imprimerie de E. Martinet, 1865. 8vo (224 x 140mm). Half title, 12-pages of publisher's advertisements at the end (some staining). Original grey printed wrappers, uncut (book block broken into 3, stain on upper wrapper, some fraying to backstrip). Provenance: From the Collection of Peter and Margarethe Braune. FIRST EDITION, second issue, of "probably the greatest classic on the principles of physiological investigation and of the scientific method as applied to the life sciences" (Garrison-Morton). Garrison-Morton 1766.501; Horblit One Hundred Books Famous in Science 11; Osler 1511; PMM 353: "Here Bernard presented his own personal analysis of scientific method in a manner which earned him commendation from the philosophers of science ... His discussion of method is illustrated by examples drawn from his own researches, such as led to his discovery of the role of pancreatic juice in digestion, the glycogenic function of the liver, the mechanism of curare and carbon monoxide poisoning, the production of artificial diabetes, and so on ...  [T]he Introduction was an important didactic work which biologists of the last hundred years have found of great interest and value"; Waller 951.